Borderline Personality Disorder Medication

Treatment Options for Borderline Personality Disorder

Borderline Personality Disorder (BPD) is a mental health condition that requires individualized and closely monitored treatment. While no medications are specifically approved by the U.S. Food and Drug Administration (FDA) for BPD, certain pharmaceutical drugs can be prescribed to alleviate symptoms such as mood swings, depression, impulsivity, and aggression. It’s important to note that medication is not the first-line treatment for BPD, but it may be combined with other therapies. Let’s explore the different classes of medications commonly prescribed for BPD and some newer treatments being investigated.


Antidepressants are the most commonly prescribed medications for individuals with BPD, with about 80% of patients using them. Selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs) are the two main antidepressants studied for BPD treatment.

SSRIs increase serotonin levels in the brain, which plays a role in mood management. Commonly prescribed SSRIs for BPD include Prozac (fluoxetine), Luvox (fluvoxamine), and Paxil (paroxetine).

MAOIs, the first drugs developed to treat depression, work by blocking an enzyme called monoamine oxidase that breaks down neurotransmitters in the brain. Nardil (phenelzine) and Parnate (tranylcypromine) are MAOIs that have effectively improved depression and impulsive aggression in BPD patients.

Mood Stabilizers and Anticonvulsants

Mood stabilizers and anticonvulsants may be prescribed to address symptoms like anger, mood swings, and impulsivity in BPD. These medications are commonly used for bipolar disorder and have also shown some benefits for BPD.

Commonly prescribed mood stabilizers and anticonvulsants for BPD include Tegretol (carbamazepine), Depakote (divalproex sodium), Lamictal (lamotrigine), Eskalith (lithium carbonate), and Topamax (topiramate). Each medication targets different symptoms and should be carefully monitored by a healthcare provider.


Antipsychotic medications can be used to manage anger issues often associated with BPD. Atypical antipsychotics, such as Abilify (aripiprazole) and Zyprexa (olanzapine), have effectively improved affective symptoms, impulsivity, aggression, and overall functioning in individuals with BPD. However, the long-term risks and benefits of antipsychotic use in BPD are still being studied.

Typical antipsychotics like Prolixin Decanoate (fluphenazine decanoate) and Haldol (haloperidol) may be used to treat suicidality, self-injurious behaviour, paranoia, and anger in some BPD patients. Loxitane (loxapine) and Navane (thiothixene) have also shown promise in improving certain symptoms of BPD.


People with BPD may experience intense anxiety for varying durations. In such cases, anti-anxiety medications, also known as anxiolytics, may be prescribed to relieve extreme agitation and distress temporarily. However, anxiolytics’ usefulness for BPD treatment has not been extensively studied.

Borderline Personality Disorder Medication in Canada

In Canada, the approach to medication for Borderline Personality Disorder (BPD) is similar to that in the United States. While Health Canada approves no specific medications for BPD, certain pharmaceutical drugs may be prescribed off-label to manage symptoms associated with the condition. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs), are commonly prescribed to help alleviate mood swings, depression, and impulsivity. Mood stabilizers and anticonvulsants, like carbamazepine and lamotrigine, may be used to address anger and mood fluctuations. In addition, antipsychotics and anxiolytics may be prescribed to manage aggression and anxiety. It is important for individuals in Canada to consult with their healthcare providers to determine the most suitable medication options for their specific needs.

Medical Disclaimer:

The information provided in this blog post is for educational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this blog post.

The content on this blog post is not intended to endorse or recommend any specific medication, treatment, or healthcare provider. Every individual is unique, and treatment plans should be tailored to their specific needs and circumstances. The availability, efficacy, and potential risks of medications mentioned in this blog post may vary depending on factors such as geographical location and individual medical history.

Reliance on any information provided in this blog post is solely at your own risk. The authors and creators of this blog post disclaim any liability for any adverse effects or consequences resulting from using or applying the information provided herein. It is important to consult with a qualified healthcare professional before starting, changing, or discontinuing any medication or treatment plan.

Furthermore, please note that medical knowledge is constantly evolving, and new research may emerge that could alter the understanding or recommendations on BPD medications. Therefore, it is essential to stay informed about updates in the field of medicine and consult with healthcare professionals to ensure the most up-to-date and appropriate care for your specific condition.


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